
After the death of a close friend, Cindy Campbell (Faris) enters a house which is believed to be haunted. Cindy is still recovering from a terrible past and hoping to start again. Living next door to her is recently divorced Tom Ryan (Bierko), who Cindy feels could be what’s missing from her life. But things start getting ugly again, when aliens appear on Earth and start destroying humanity. The little Japanese Ghost Boy (Masuda) gives Cindy information on how to stop the aliens. She must travel with her friend Brenda Meeks (Hall) to a village where civilization is very different.
Anna Faris and Regina Hall are back as the lovable, dim-witted Cindy Campbell and her self-serving, sex-crazed pal Brenda respectively. They are joined this time around by Craig Bierko as the cute, but utterly clueless, Tom Ryan. Together, they battle to save the world from a ruthless alien invasion. Cindy Campbell moves in next to Tom Ryan because she’s taking care of an old lady. She finds out the house is haunted by a little boy and goes on a quest in the village to find out who killed him and why. Also, Alien “Tr-iPods” are invading the world and Cindy has to uncover the secret in order to stop them.